This 756-acre wildlife area is located about 1½ miles northeast of Fredericktown. Knox Lake is historically one of the best largemouth bass fisheries in the state and is heavily targeted for large trophy flathead catfish. Other fishing opportunities include black and white crappie, bluegill, channel catfish, and yellow perch.
Knox Lake is a great place to spot migrating waterfowl in during the spring and fall migrations. Ospreys, bald eagles, and several species of hawks can also be seen. Hunters can pursue waterfowl at Knox Lake Wildlife Area. The northern part of the lake is popular for waterfowl hunting and has a strong population of Canada geese. Wood ducks also frequent the area. Aquatic vegetation allows for cover. Knox Lake falls within the North Zone for waterfowl hunting. Be sure to familiarize yourself with the regulations for the North Zone for this area. Small game, turkey, and deer can be pursued in the forested areas along the lakeshore.